Wednesday, January 16, 2013

MIT Sues Shire Alleging that Dermagraft Infringes Cell-Scaffold Patents


On January 4, 2013, MIT sued Shire Pharmaceuticals in the District of Massachusetts for infringing US Patent Numbers 5,759,830; 5,770,417; and 5,770,193. The patents all issued in 1998, and are generally directed towards “three-dimensional fibrous scaffolds containing attached cells for producing vascularized tissue in vivo.”  For example, claim 1 of the ‘830 patent recites:
1. A cell-scaffold composition prepared in vitro for growing cells to produce functional vascularized organ tissue in vivo, comprising:
a fibrous three-dimensional scaffold composed of fibers of a biocompatible, biodegradable, synthetic polymer; and
cells derived from a vascularized tissue attached in vitro to the surface of the fibers of the scaffold uniformly throughout the scaffold;
wherein the fibers of the scaffold provide sufficient surface area to permit attachment in vitro of an amount of the cells effective to produce the functional vascularized organ tissue in vivo;
wherein the fibers of the scaffold are spaced apart such that the maximum distance over which diffusion of nutrients and gases must occur through a mass of cells attached to the fibers is between 100 and 300 microns; and
wherein the diffusion provides free exchange of nutrients, gases and waste to and from the cells uniformly attached to the fibers of the scaffold and proliferating throughout the scaffold in an amount effective to maintain cell viability throughout the scaffold in the absence of vascularization.
The allegedly infringing product is Dermagraft, a human fibroblast-derived dermal substitute approved by FDA in 2001 for use in treatment of full thickness diabetic foot ulcers. According to the complaint, Dermagraft is manufactured from human fibroblast cells derived from newborn foreskin tissue, which are seeded onto a bioabsorbable polyglactin three-dimensional mesh scaffold. MIT alleges that the fibroblasts proliferate to fill the interstices of this scaffold and secrete human dermal collagen, matrixproteins, growth factors,  and cytokines to create a three-dimensional human dermal substitute containing metabolically active,  living cells.

 

16 comments:

Manohar Singh said...

[url=http://www.monarch-garments.com/cat_sherwani.asp]http://www.monarch-garments.com/cat_sherwani.asp[/url]
Sherwani
We have formed our special style in all kinds of thermometers and other instruments,
http://www.monarch-garments.com/cat_sherwani.asp

Tom Smith said...

I like see your blog!
Bail Bonds Raleigh

Josh Green Rock said...

Nice blog!
Bail Bonds Las Vegas

Harry Salvin said...

I really appreciate your words, thanks for sharing it.

regards
Bail Bonds Los Angeles

PENNY STOCK INVESTMENTS said...

These patent lawsuite are out of control.

Job board for my company said...

This is a amazing inspiring composition.I am gorgeous plenty pleased among your salubrious process.You put truly really cooperative info.Job board for my company

limousinestoairport.ca said...

Your blog specializing in going above the certain lacking a apprehension contemptuous along on their possess released constrains.limousinestoairport.ca

procurement software said...

I want to express my admiration of your writing skill and ability to make readers read from the beginning to the end.procurement software

forex bank exchange rates said...

I LOVEEE FRUGAL GIFT GIVING! THANKS AGAIN YOU ARE THE BEST!forex bank exchange rates

bow selectie said...

I have read many blogs in the net but have never come across such a well written blog. Good work keep it up bow selectie

loft conversion prices said...

Really i appreciate the effort you made to share the knowledge. The topic here i found was really effective to the topic which i was researching for a long time.loft conversion prices

legal software said...

I find it important to let the batter sit at room temperature a few minutes, so it is not so cold when it hits the waffle iron). Also try the Carrot Nutritive Day Creme or Night Creme because it contains beta-carotene, the product is very sweet-smelling however so take note if you do have a sensitive nose.legal software

home decorating southwest style | mission del rey southwest said...

Thanks for the great information. Like a lot of people with hypothyroidism, I started looking for deitary ways to control my condition.home decorating southwest style | mission del rey southwest

Buy White Wine said...

Thanks for information top company best services provide the 5th in packing and moving services Buy White Wine

qualifying for a construction loan said...

would wish to invite my other friends to the current web site, as you have got done an excellent job I will have to say...keep it up guys...Thanks for the knowledge. I appreciate every and each point of your article. Very nice info .Keep sharing…qualifying for a construction loan

bulk canvas tote bags cheap said...

wow, great, I was wondering how to cure acne naturally. and found your site by google, learned a lot, now i’m a bit clear. I’ve bookmark your site and also add rss. keep us updated.bulk canvas tote bags cheap